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| Frankie Ramos is "bad boy" Tony Perez the unlikely lover of "good girl" Negra and boyfriend of clingy and jealous Lourdes |
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| Irma Cadiz reprises the role of Lourdes |
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| Anissa Smith is the tormented Negra Centron |
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| Wanda Ramos is the mysterious Santeria priestess, Iya Carmen, who counsels Negra's vexed mother |
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| Tina Moore plays the eccentric mother of Negra, vexed by her daughter's relationship with Tony Perez |
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| Evan Davis plays Tony's best friend and partner in crime, Bobby Vico |
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| Michelle Lamelza play the wife and "Italian Princess" of Bobby, Barbara Vico |
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| Billy Barry plays blue blood, pompous cardiologist and Negra's amorous boss Dr. Todd Turnbull Adams |
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| Stacey Griffin reprises the role of the condescending successful professional Clinton Williams from the Off Broadway run of "A Wound In Time" |
